Annual Report 2023-2024

2024 Shriners Children's Funded Multi-site Clinical Research Projects Defining treatment outcomes and genetic architecture in Locations: Canada, with Chicago,

Miserable malalignment syndrome: improving management through evidence based research Principal Investigator:

Locations: Chicago, with Northern California, Philadelphia, Portland and Texas Genetic and developmental underpinnings of hemifacial macrosomia Principal Investigator: Eric Liao, M.D., Ph.D. Locations: Philadelphia, with Chicago Machine learning and functional validated analysis of orofacial cleft Principal Investigator: Eric Liao, M.D., Ph.D. Locations: Philadelphia, with Chicago A new measure for health outcomes in teenagers with burns Principal Investigator: Colleen Ryan, M.D. Locations: Boston, with Northern California and Texas Preschool Life Impact Burn Recovery Evaluation Implementation Principal Investigator: Colleen Ryan, M.D. Locations: Boston, with Northern California and Texas

Portland, Greenville, Northern California and Philadelphia Elucidating the Genetic Architecture of Cerebral Palsy Principal Investigator: Jon Davids, M.D. Locations: Northern California, with Portland, Shreveport, Chicago, Greenville, Philadelphia, Mexico and Salt Lake City Validation of the Pediatric Appraisals of DisAbility Primary and Secondary Scale Principal Investigator: Kyle Deane, Ph.D. Locations: Chicago, with Philadelphia Decoding Motor Intent for Hand Prosthesis Control Principal Investigator: Michelle James, M.D. Locations: Northern California, with Chicago, Greenville and Portland Improving Orthopedic Outcomes with Machine Learning Principal Investigator: Joseph Krzak, Ph.D.

idiopathic toe walking Principal Investigator: Jeremy Bauer, M.D. Locations: Portland, with Chicago, Greenville, Lexington, Northern California, Philadelphia, Salt Lake City and Spokane FUSION: Forecasting Unexpected Signal changes in pOsterior spinal fusioN Principal Investigator: Bruce Brenn, M.D. Locations: Philadelphia,

Louis-Nicolas Veilleux, Ph.D.

Locations: Canada, with Chicago and Portland

Expanding LEADeR, a Lower Extremity Amputation and Deficiency Registry Principal Investigator: Janet Walker, M.D. Locations: Lexington, with Canada, Chicago, Greenville, Northern California, Philadelphia, Shreveport and Texas Using advanced analytic modeling to examine the role of biologic, genomic and radiographic measures play in the prediction of growth, growth cessation and curve progression in idiopathic scoliosis Principal Investigator: Michelle Welborn, M.D. Locations: Portland, with Southern California, Chicago, Lexington, Northern California and Philadelphia

with Chicago and Greenville

EXPAND Arthrogryposis Multiplex Congenita (AMC)

Principal Investigator: Noemi Dahan, Ph.D. Locations: Canada, with Chicago, Greenville, Mexico, Northern California, Philadelphia, Portland and Shreveport Psychometrics and usefulness of the SHAPE-UP measure Principal Investigator: Noemi Dahan, Ph.D.

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