SC Portland Outcomes Report 2023

Innovative research at Shriners Children’s Portland has made remarkable strides in recent years, especially with the biomarker study informing better treatment timelines for scoliosis bracing.

1986 Mutations in collagen

1986 Research on type VI collagen microfilaments leads to important findings about its role in certain Muscular Dystrophies.

1986 Extending knowledge on Type III collagen and its role in Vascular Ehlers Danlos Syndrome.

molecules are shown to lead to structural defects in the many forms of Osteogenesis Imperfecta (also known as Brittle Bone Disease).

1996 Discovery of the role of collagen X in the growth plate of cartilage which acts as a real-time indicator for bone growth. A patent for this blood test was issued in 2018.

1996 A mutation in a small cartilage protein COMP is found to result in the dwarfing disorder “Pseudoachondroplasia.”

1991 Mutations in the Fibrillin-1 gene are found to cause Marfan syndrome. As a result of this work, there is now a diagnostic test for Marfan syndrome.

2022 Shriners Children’s Portland, under the direction of Jeremy Bauer, M.D., leads a multicenter study with seven other Shriners Children’s locations to determine screening tools for accurate diagnosis, examine the outcomes from either casting or surgery and determine whether there is a genetic link for children with idiopathic toe walking.

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